Here, we identify BORIS in the cytoplasm and nucleus of a wide range of normal and cancer cells. However, the expression pattern of BORIS is both a significant and unresolved question in the field of DNA binding proteins. Unlike CTCF, BORIS expression has been reported only in the testis and certain malignancies, leading to its classification as a “cancer-testis” antigen. BORIS and CTCF have virtually identical zinc finger domains, yet display major differences in their respective C- and N-terminal regions. On Monday MPs will be given a free vote on whether to endorse the committee's report and whether to remove Mr Johnson's pass to the parliamentary estate.BORIS (CTCFL) is the paralog of CTCF (CCCTC-binding factor NM_006565), a ubiquitously expressed DNA-binding protein with diverse roles in gene expression and chromatin organisation. Liberal Democrat leader Sir Ed Davey said following the publication of the report that Mr Johnson was a "liar and law-breaker" who has "treated the public with utter disdain". He accused Sir Bernard Jenkin of "monstrous hypocrisy" after the Guido Fawkes website reported the MP had gone to a drinks party in parliament held by Commons Deputy Speaker Dame Eleanor Laing while COVID restrictions were in place in 2020.īut Mr Johnson was accused of attempting to distract from the report's findings by opposition MPs, while a source close to the committee reportedly dismissed the intervention as "desperate stuff". In a last-ditch attempt to disparage the Tory-majority panel on the eve of publication, he called for its most senior Conservative member to resign. The publication of the report comes after Mr Johnson dramatically quit as an MP on Friday after receiving its draft findings. The ex-PM has repeatedly asserted he believed one Number 10 leaving do - where he was seen toasting colleagues to mark the departure of communications chief Lee Cain - was "absolutely essential for work purposes".īut the committee again found against him, saying it did not believe that "severe staff morale pressures during the COVID pandemic… in itself provided a licence for Mr Johnson's conveniently flexible interpretation of the rules on gatherings, or the guidance on social distancing." In coming to its conclusion, the MPs did not find Mr Johnson's defence that no one had advised him the gatherings were against the rules as credible. Johnson had 'personal knowledge' of gatherings "This is a dreadful day for MPs and for democracy," he said, adding its investigation had delivered "what is intended to be the final knife-thrust in a protracted political assassination". He took particular aim at Ms Harman, saying the "terrible truth is that it is not I who has twisted the truth to suit my purposes - it is Harriet Harman and her committee". ![]() ![]() The former prime minister immediately hit back at what he called a "deranged conclusion" and branded the committee's report a "charade", adding: "I was wrong to believe in the committee or its good faith." 'Final knife-thrust in a protracted political assassination' What does the partygate report say? Sky's Joe Pike explains
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